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Proposed model for the mechanism of HSP90-HDAC6 regulating network and implication in breast cancer treatment A-C. Proposed molecular mechanism driving breast cancer cells sensitive to HSP90 inhibition and HDAC6 inhibition. D. HSP90 inhibitor 17-DMAG inhibited tumor growth in TNBC cell xenograft mouse model. E. HDAC6 inhibitor Tubacin inhibited tumor growth in tamoxifen-resistant breast cancer cell xenograft mouse model. Each group was compared with control group, *P<0.05.
