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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: J Am Chem Soc. 2017 Jan 17;139(4):1448–1451. doi: 10.1021/jacs.6b12819

Figure 1.

Figure 1

Gram-negative peptidoglycan recycling and its role in AmpR-regulated AmpC β-lactamase induction is depicted. Cell wall is degraded by lytic transglycosylases (LTs) in the periplasm in a process that involves an oxocarbenium (the structure in the brackets), which entraps the C6 hydroxyl to give the 1,6-anhydromuramyl species.11 Compounds 1 are key muropeptides that are involved in signaling events that lead to induction of the AmpC β-lactamase.