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. Author manuscript; available in PMC: 2017 May 18.
Published in final edited form as: Methods Mol Biol. 2016;1425:325–337. doi: 10.1007/978-1-4939-3609-0_14

Table 1. Bradford-Hill criteria for AOP weight-of-evidence assessment (1, 9, 13).

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    Concordance of dose-response relationships.

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    Temporal concordance among the KEs and AO.

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    Strength, consistency and specificity of association of the AO and the MIE.

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    Biological plausibility, coherence and consistency of the experimental evidence.

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    Alternative mechanisms that logically present themselves and the extent to which they may distract from the postulated AOP.

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    Uncertainties, inconsistencies and data gaps.