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. Author manuscript; available in PMC: 2017 May 18.
Published in final edited form as: Methods Mol Biol. 2016;1425:325–337. doi: 10.1007/978-1-4939-3609-0_14

Table 2. Key questions for testing AOP confidence (1, 9).

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    How well characterized is the AOP?

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    How well are the MIE and KEs causally linked to the AO?

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    What are the limitations in the evidence in support of the AOP?

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    Is the AOP specific to certain tissues, life stages or age classes?

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    Are the MIE and KEs expected to be conserved across taxa?