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. Author manuscript; available in PMC: 2017 May 18.
Published in final edited form as: Methods Mol Biol. 2016;1425:325–337. doi: 10.1007/978-1-4939-3609-0_14

Table 3. Major challenges for future AOP development.

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    Complying with the overall complexity of toxicological processes.

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    Quantification and inclusion of dose-response relationships.

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    Implementation of exposure data.

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    Implementation of toxicokinetic data.

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    Establishment of a transparent and objective evaluation system.