Table 1. Deaths and YLLs From the 30 Leading Diseases and Injuries Contributing to YLLs in the United States in 1990 and 2010 and Percentage Change From 1990 to 2010 in YLLs and Age-Standardized YLL Ratesa.
| Diseases and Injuries | YLL Rank | Deaths | YLLs | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1990 | 2010 | No. (in Thousands) | Median Change, % | No. (in Thousands) | Median Change, % | |||||
| 1990 | 2010 | Deaths | Age-Standardized Death Rate | 1990 | 2010 | YLLs | Age-Standardized YLL Rate | |||
| Ischemic heart disease | 1 (1-1) | 1 (1-1) | 648.2 (600.8-676.1) | 562.9 (515.4-662.1) | −14.4 (−20.6 to 2.6) | −43.6 (−47.1 to −33.2) | 8990.3 (8386.2-9451.4) | 7164.5 (6706.6-8198.2) | −21.2 (−25.6 to −9.1) | −45.2 (−48.2 to −38.1) |
| Lung cancer | 2 (2-3) | 2 (2-2) | 143.5 (116.8-178.5) | 163.3 (128.1-200.8) | 14.4 (−1.1 to 26.0) | −22.5 (−31.8 to −14.7) | 2871.9 (2325.8-3523.2) | 2987.7 (2418.1-3731.2) | 3.6 (−6.6 to 17.4) | −30 (−36.1 to −18.9) |
| Stroke | 4 (3-4) | 3 (3-5) | 177.8 (163.7-200.9) | 172.3 (153.5-201.7) | −3 (−13.6 to 8.2) | −36.7 (−43.0 to −30.4) | 2250.4 (2096.3-2543.6) | 1945.3 (1741.8-2147.8) | −13.2 (−21.5 to −6.2) | −39.3 (−45.6 to −34.8) |
| Chronic obstructive pulmonary disease | 5 (5-8) | 4 (3-5) | 97.5 (90.3-105.5) | 154.5 (137.8-170.0) | 58.3 (43.3 to 75.7) | 5.6 (−3.0 to 16.3) | 1416.1 (1308.5-1534.0) | 1913.1 (1720.9-2067.9) | 34.7 (24.7 to 47.1) | −5.8 (−12.5 to 2.7) |
| Road injury | 3 (2-4) | 5 (3-6) | 49.6 (43.4-59.2) | 44.0 (36.2-53.5) | −11.7 (−21.8 to 3.4) | −30.2 (−37.5 to −17.7) | 2336.5 (2022.5-2752.3) | 1873.2 (1569.0-2280.1) | −20.4 (−28.4 to −4.3) | −33.3 (−39.7 to −19.4) |
| Self-harm | 6 (5-10) | 6 (5-10) | 33.7 (25.6-43.7) | 37.3 (27.6-47.1) | 10.8 (−6.2 to 26.7) | −12.9 (−27.2 to −1.6) | 1393.8 (1068.6-1808.7) | 1456.9 (1066.1-1779.0) | 5.7 (−13.2 to 18.1) | −13.2 (−28.3 to − −2.4) |
| Diabetes | 15 (11-15) | 7 (6-9) | 50.2 (45.3-60.0) | 86.1 (73.0-99.3) | 71.8 (43.7 to 97.1) | 17.3 (−1.3 to 32.4) | 875.0 (788.0-1042.3) | 1392.4 (1186.7-1568.1) | 60.1 (34.5 to 78.3) | 13.0 (−5.4 to 25.7) |
| Cirrhosis | 14 (10-15) | 8 (7-12) | 35.5 (31.3-42.1) | 49.5 (39.5-54.6) | 43.3 (14.0 to 56.0) | −2 (−22.5 to 6.4) | 917.3 (808.7-1095.1) | 1232.7 (966.2-1364.7) | 37.9 (9.8 to 50.8) | −5.3 (−23.8 to 3.3) |
| Alzheimer disease | 32 (23-38) | 9 (6-20) | 27.0 (19.8-45.7) | 158.3 (75.8-237.4) | 524.3 (136.8 to 877.4) | 289.6 (56.5 to 487.6) | 257.4 (202.1-407.1) | 1192.4 (637.0-1648.1) | 391.6 (128.5 to 593.1) | 209.5 (60.4 to 315.7) |
| Colorectal cancer | 11 (9-14) | 10 (7-13) | 60.2 (49.6-67.1) | 63.9 (55.4-88.1) | 1.6 (−9.4 to 49.7) | −29.4 (−36.1 to 2.4) | 1018.9 (855.4-1127.3) | 1073.6 (946.9-1412.7) | 1.6 (−7.6 to 41.8) | −27.5 (−33.9 to −0.8) |
| Lower respiratory tract infections | 10 (7-11) | 11 (8-13) | 90.4 (71.9-103.3) | 85.4 (69.4-114.0) | −8.1 (−27.8 to 34.7) | −38.6 (−49.7 to −14.1) | 1185.7 (996.4-1303.8) | 1031.8 (905.9-1261.3) | −14.3 (−26.1 to 8.4) | −37.6 (−44.9 to −26.1) |
| Interpersonal violence | 8 (5-13) | 12 (7-16) | 25.2 (17.7-30.9) | 19.9 (15.9-28.3) | −24.4 (−33.8 to 8.2) | −34.4 (−42.7 to −7.9) | 1344.3 (948.9-1660.1) | 1019.1 (795.8-1427.6) | −26.5 (−36.0 to 2.9) | −33.9 (−42.8 to −8.9) |
| Breast cancer | 12 (11-14) | 13 (12-16) | 43.2 (40.4-47.0) | 42.6 (37.4-47.5) | −1.2 (−12.6 to 10.0) | −33.4 (−40.0 to −26.6) | 953.7 (890.0-1020.1) | 891.7 (804.6-980.7) | −6.5 (−14.3 to 2.4) | −35.9 (−41.0 to −29.8) |
| Preterm birth complications | 9 (6-12) | 14 (11-18) | 14.1 (11.3-16.8) | 10.0 (8.0-12.3) | −29.6 (−45.9 to −5.1) | −35.7 (−50.5 to −13.3) | 1213.2 (970.1-1440.7) | 858.4 (687.4-1061.3) | −29.6 (−45.9 to −5.1) | −35.7 (−50.5 to −13.3) |
| Drug use disorders | 44 (24-49) | 15 (8-28) | 3.8 (2.6-8.5) | 19.4 (9.3-28.6) | 477.4 (105.1 to 699.8) | 376.6 (69.3 to 559.6) | 174.1 (118.4-399.1) | 840.6 (387.6-1239.2) | 448.4 (88.0 to 673.8) | 376.6 (65.3 to 565.7) |
| Chronic kidney disease | 21 (19-25) | 16 (13-20) | 30.4 (26.0-37.5) | 60.3 (47.4-74.0) | 99 (58.8 to 141.4) | 33.9 (7.8 to 59.2) | 425.2 (374.2-521.6) | 780.2 (636.7-908.4) | 85.8 (47.4 to 112.2) | 32.4 (4.2 to 49.9) |
| Other cardiovascular/circulatory | 16 (16-18) | 17 (15-19) | 40.9 (38.6-43.3) | 56.6 (50.5-63.7) | 38.2 (21.8 to 57.2) | −8.7 (−17.8 to 1.0) | 636.1 (611.3-662.0) | 765.4 (709.1-824.0) | 20.3 (10.2 to 30.2) | −14.4 (−21.1 to −7.6) |
| Pancreatic cancer | 19 (16-23) | 18 (13-23) | 28.6 (21.7-39.1) | 39.0 (28.7-52.8) | 37 (15.5 to 58.7) | −4.9 (−19.0 to 8.4) | 508.6 (391.5-669.5) | 679.9 (500.1-908.3) | 34.3 (15.2 to 51.4) | −6.3 (−19.8 to 5.6) |
| Congenital anomalies | 13 (11-15) | 19 (15-22) | 13.4 (11.2-15.8) | 12.4 (10.8-15.1) | −8.3 (−18.1 to 8.2) | −32.3 (−39.0 to −14.7) | 937.1 (762.0-1086.5) | 660.8 (579.6-842.1) | −31.3 (−39.0 to −6.8) | −41.1 (−48.1 to −18.3) |
| Cardiomyopathy | 18 (16-19) | 20 (13-22) | 30.7 (26.2-32.7) | 36 (30.9-46.7) | 15.4 (−1.0 to 71.3) | −22.9 (−32.6 to 18.0) | 622.7 (533.7-659.8) | 659.4 (571.7-908.0) | 3.3 (−9.8 to 63.1) | −24.2 (−34.1 to 18.2) |
| Hypertensive heart disease | 17 (16-19) | 21 (16-23) | 41.4 (33.2-51.4) | 44.7 (34.8-59.6) | 7.4 (−10.5 to 30.6) | −29.1 (−39.2 to −15.7) | 625.8 (522.0-768.2) | 641.9 (531.5-800.8) | 2.2 (−10.3 to 18.1) | −28.1 (−37.2 to −18.7) |
| Leukemia | 20 (19-24) | 22 (21-29) | 20.3 (16.4-25.3) | 25.5 (20.0-31.6) | 25.9 (3.3 to 45.1) | −13 (−25.2 to −2.7) | 458.3 (373.9-562.8) | 493.6 (402.2-611.1) | 7.8 (−3.7 to 19.3) | −20.5 (−28.9 to −11.1) |
| Human immunodeficiency virus/AIDS | 7 (5-9) | 23 (22-27) | 28.6 (25.6-31.9) | 12.1 (10.6-13.7) | −57.7 (−63.5 to −50.5) | −67.7 (−72.1 to −62.3) | 1351.1 (1201.1-1508.5) | 479.2 (417.4-542.2) | −64.5 (−69.6 to −58.1) | −71.6 (−75.8 to −66.5) |
| Kidney cancers | 35 (28-45) | 24 (16-31) | 10.7 (7.5-14.2) | 24.4 (17.1-39.8) | 114.9 (60.0 to 262.5) | 47 (9.7 to 146.3) | 216.9 (152.7-282.0) | 475.7 (334.5-796.4) | 104.7 (53.1 to 247.1) | 40.9 (5.7 to 144.0) |
| Non-Hodgkin lymphoma | 22 (20-26) | 25 (22-30) | 20 (16.8-23.5) | 25.2 (20.3-30.2) | 25.4 (2.4 to 52.4) | −14.6 (−28.0 to 3.5) | 407.8 (339.9-465.4) | 451.6 (375.7-541.7) | 8.6 (−5.7 to 38.5) | −23.6 (−33.4 to −0.2) |
| Poisonings | 31 (22-38) | 26 (18-45) | 5.9 (4.5-9.6) | 11.4 (4.2-16.2) | 117.1 (−34.4 to 229.4) | 76.1 (−46.7 to 173.3) | 263.6 (201.7-433.8) | 485.7 (172.9-693.0) | 108.1 (−39.3 to 220.0) | 74.3 (−48.1 to 173.5) |
| Prostate cancer | 23 (18-35) | 27 (16-35) | 30.8 (16.6-44.3) | 35.9 (20.8-65.4) | 9.7 (−30.0 to 89.7) | −25.2 (−49.5 to 26.6) | 417.9 (223.7-599.7) | 445.6 (250.9-787.1) | −1.6 (−30.1 to 62.4) | −29.6 (−48.8 to 15.5) |
| Brain cancer | 24 (19-31) | 28 (21-34) | 14 (9.8-21.1) | 16.5 (10.9-24.4) | 18 (−8.1 to 45.3) | −18 (−33.4 to −3.4) | 383.3 (262.8-551.6) | 411.2 (279.8-611.0) | 7.1 (−9.9 to 26.9) | −22 (−33.8 to −7.5) |
| Falls | 33 (26-36) | 29 (24-35) | 14.5 (12.1-19.7) | 31.6 (18.7-41.7) | 136.4 (11.3 to 220.9) | 52 (−25.4 to 96.0) | 245.4 (215.5-321.9) | 400.2 (265.4-489.2) | 79.3 (−3.6 to 117.3) | 20.9 (−30.3 to 42.9) |
| Liver cancer | 39 (33-43) | 30 (25-35) | 9.3 (8.3-11.9) | 19.5 (13.3-22.7) | 118.4 (36.1 to 151.3) | 55.3 (−4.9 to 76.4) | 184.7 (167.7-235.4) | 398.9 (260.6-461.5) | 125.5 (34.9 to 156.5) | 58.5 (−6.4 to 80.5) |
a
Diseases and injuries contributing to years of life lost due to premature mortality (YLLs) are ranked by the magnitude of YLLs in 2010. 95% uncertainty intervals are shown in parentheses for all data.