Table 2. YLD Numbers in 1990 and 2010 for Both Sexes Combined for the 30 Leading Diseases and Injuries Contributing to YLDs in 2010 in the United States and Percentage Change From 1990 to 2010, Ranked by the Magnitude of YLDs in 2010a.
| Diseases and Injuries | YLD Rank | No. of YLDs (in Thousands) | Median Change, % | |||
|---|---|---|---|---|---|---|
| 1990 | 2010 | 1990 | 2010 | YLDs | Age-Standardized YLD Rate | |
| Low back pain | 1 (1-3) | 1 (1-3) | 2538.00 (1771.4-3427.2) | 3180.60 (2179.5-4318.6) | 24.9 (13.8 to 38.4) | − 3 (− 11.6 to 7.3) |
| Major depressive disorder | 2 (1-5) | 2 (1-4) | 2142.50 (1525.2-2843.7) | 3048.90 (2151.3-4122.3) | 42.7 (9.2 to 83.3) | 13.4 (− 12.9 to 46.3) |
| Other musculoskeletal disorders | 3 (1-4) | 3 (2-4) | 2024.40 (1664.7-2311.9) | 2602.50 (2138.0-2986.8) | 28.5 (18.9 to 38.9) | − 0.2 (− 8.0 to 7.8) |
| Neck pain | 4 (2-6) | 4 (2-6) | 1652.70 (1151.0-2296.4) | 2134.40 (1482.6-2934.4) | 29.1 (17.4 to 41.1) | 0.2 (− 9.1 to 9.5) |
| Anxiety disorders | 5 (2-6) | 5 (3-6) | 1541.00 (1078.5-2172.8) | 1866.10 (1310.2-2569.3) | 21.3 (4.7 to 39.5) | − 1.5 (− 15.2 to 13.1) |
| Chronic obstructive pulmonary disease | 6 (4-9) | 6 (3-10) | 1304.10 (761.3-2007.2) | 1745.40 (1011.9-2601.4) | 34.1 (4.6 to 70.9) | − 1.5 (− 23.2 to 25.0) |
| Drug use disorders | 7 (6-10) | 7 (6-10) | 996.9 (722.3-1337.9) | 1295.50 (921.6-1725.1) | 29.8 (6.5 to 58.6) | 20.1 (− 1.4 to 47.1) |
| Diabetes | 8 (7-15) | 8 (6-11) | 747.7 (506.1-1059.3) | 1164.90 (789.1-1648.6) | 56.2 (38.4 to 74.8) | 11.2 (− 1.4 to 24.5) |
| Osteoarthritis | 12 (8-19) | 9 (7-17) | 637.6 (393.1-972.0) | 994 (611.5-1471.0) | 56.1 (28.3 to 88.3) | 5.5 (− 13.7 to 27.8) |
| Asthma | 9 (7-19) | 10 (7-19) | 769.3 (418.1-1229.5) | 932 (504.7-1469.3) | 21.2 (11.5 to 31.6) | − 0.8 (− 9.4 to 8.2) |
| Falls | 15 (10-20) | 11 (9-18) | 561.9 (381.4-801.1) | 864.3 (588.6-1224.8) | 54.1 (33.1 to 80.0) | 9.6 (− 6.4 to 29.4) |
| Alzheimer disease | 17 (12-21) | 12 (10-17) | 532.2 (375.9-714.7) | 829.9 (594.9-1090.8) | 56 (43.9 to 68.9) | 3.8 (− 4.1 to 11.8) |
| Alcohol use disorders | 10 (8-17) | 13 (8-19) | 688.1 (437.3-1018.7) | 835.7 (535.8-1222.1) | 21.4 (-10.3 to 63.6) | − 1.6 (− 27.3 to 32.6) |
| Migraine | 11 (8-18) | 14 (8-19) | 676.8 (444.7-938.5) | 805 (525.4-1136.3) | 18.9 (5.5 to 34.4) | − 2.6 (− 13.8 to 10.0) |
| Schizophrenia | 13 (8-19) | 15 (8-20) | 644.2 (410.3-884.9) | 825.3 (527.8-1150.1) | 27.9 (16.5 to 40.4) | − 1.8 (− 11.1 to 8.0) |
| Ischemic heart disease | 16 (10-21) | 16 (10-21) | 547.1 (351.0-797.0) | 685 (452.2-975.1) | 25.4 (12.9 to 40.6) | − 14.3 (− 22.6 to − 4.3) |
| Stroke | 23 (20-28) | 17 (14-20) | 320.5 (263.3-375.9) | 628.7 (520.2-729.0) | 96.4 (82.6 to 110.9) | 40 (30.4 to 49.6) |
| Bipolar disorder | 18 (10-25) | 18 (11-26) | 481 (304.6-709.5) | 578 (358.3-854.8) | 20.3 (2.2 to 40.7) | 1.4 (− 14.0 to 18.8) |
| Other hearing loss | 14 (7-22) | 19 (11-26) | 585.3 (336.5-967.1) | 559.2 (322.5-916.4) | -4.3 (-17.2 to 10.1) | − 34.1 (− 43.4 to − 23.8) |
| Dysthymia | 19 (12-27) | 20 (14-27) | 435.9 (286.5-606.0) | 545.5 (355.1-765.3) | 25 (12.3 to 40.3) | − 1.2 (− 11.4 to 10.7) |
| Sickle cell disorder | 21 (11-30) | 21 (14-30) | 372.6 (202.6-729.4) | 472 (272.3-882.5) | 28.4 (-21.5 to 109.4) | 10.2 (− 33.9 to 86.1) |
| Chronic kidney disease | 27 (21-30) | 22 (19-29) | 285.2 (203.9-372.1) | 410.4 (294.3-545.6) | 43.8 (28.5 to 61.3) | 4.4 (− 6.7 to 17.9) |
| Rheumatoid arthritis | 24 (20-30) | 23 (20-29) | 313.9 (223.9-409.4) | 403.1 (288.2-528.3) | 28.3 (18.0 to 39.3) | − 4.8 (− 12.7 to 3.2) |
| Benign prostatic hyperplasia | 28 (21-34) | 24 (19-30) | 258.4 (167.4-389.5) | 396.8 (247.6-604.7) | 54 (17.0 to 96.3) | 3.2 (− 22.1 to 32.4) |
| Eczema | 25 (18-35) | 25 (18-34) | 303.8 (156.7-483.5) | 390.2 (202.4-619.6) | 28.7 (16.3 to 41.2) | 7.1 (− 4.0 to 18.0) |
| Road injury | 22 (18-29) | 26 (20-31) | 325.9 (214.0-470.3) | 373.1 (249.0-545.9) | 14.5 (-7.3 to 41.9) | − 9.9 (− 26.8 to 12.1) |
| Other vision loss | 29 (16-41) | 27 (14-39) | 270.6 (118.8-551.2) | 375 (162.2-762.4) | 39.3 (-20.6 to 151.1) | 0.7 (− 42.6 to 81.0) |
| Edentulism | 20 (14-28) | 28 (22-37) | 386.2 (220.2-618.2) | 314.5 (182.1-499.4) | -18.9 (-28.5 to -7.3) | − 41.9 (− 48.9 to − 33.7) |
| Diarrheal diseases | 26 (20-30) | 29 (25-36) | 293.8 (196.1-418.1) | 283.3 (189.8-409.5) | -3.4 (-14.9 to 7.2) | − 21.9 (− 31.1 to − 12.9) |
| Epilepsy | 30 (26-37) | 30 (25-37) | 208.6 (157.3-268.1) | 260.7 (199.7-334.6) | 25 (10.5 to 41.7) | 2.9 (− 9.0 to 17.0) |
Abbreviation: YLD, years lived with disability.
a
95% uncertainty intervals are shown in parentheses for all data.