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. 2017 May 18;12(5):e0177310. doi: 10.1371/journal.pone.0177310

Fig 2. Serum norovirus-specific IgG and IgA production following intranasal immunization with GelVac™ bivalent and monovalent vaccine powders.

Fig 2

Female Hartley guinea pigs were immunized intranasally with 20 mg of a bivalent vaccine powder formulation containing various amounts of GI and GII.4 VLPs on days 0 and 21. Serum samples were collected on day 0, 14, 21, 42, and 56 and analyzed for specific IgG antibodies against GI (A) and GII.4 (B). Serum samples were also analyzed for specific IgA antibodies against GI (C) and GII.4 (D). Error bars are provided as geometric standard deviation. *p<0.05 as compared to the placebo control group. Horizontal dotted line depicts the limit of detection for these assays.