Skip to main content
. 2017 May 18;12(5):e0177310. doi: 10.1371/journal.pone.0177310

Fig 3. Neutralizing antibody production following intranasal immunization with GelVac™ dry powder bivalent and monovalent vaccine.

Fig 3

Female Hartley guinea pigs were immunized intranasally with 20 mg of a bivalent vaccine powder formulation containing various amounts of GI and GII.4 VLPs on days 0 and 21. Serum samples were collected on days 0, 14, 21, 42, and 56 and analyzed for GI (A) and GII.4 (B) neutralizing antibodies. Error bars are provided as geometric standard deviation. *p<0.05 as compared to the placebo control group. Horizontal dotted line depicts the limit of detection for these assays.