Skip to main content
. 2017 May 18;12(5):e0177310. doi: 10.1371/journal.pone.0177310

Fig 4. Mucosal norovirus-specific antibody production following intranasal immunization with GelVac™ dry powder bivalent and monovalent vaccine.

Fig 4

Female Hartley guinea pigs were immunized intranasally with 20 mg of a bivalent vaccine powder formulation containing various amounts of GI and GII.4 VLPs on days 0 and 21. Vaginal lavage samples were collected on days 0, 14, 21, 42, and 56 and analyzed for GI (A) and GII.4 (B) norovirus-specific antibodies. On day 56, animals were euthanized and intestinal lavage samples were analyzed for GI (C) and GII.4 (D) norovirus-specific antibodies. Error bars are provided as geometric standard deviation. *p<0.05 as compared to the placebo control group. Horizontal dotted line depicts the limit of detection for these assays.