Table 1.

IPA networks identified via analysis of focus genes. Analysis of differentially expressed genes using IPA revealed a set of gene networks based on known interactions. Up-regulated genes are shown in (red) and down-regulated genes are shown in (green). Genes not altered in our signature are indicated in plain text. The table represents networks 1 to 5 as illustrated in Fig. 6.

Molecules in network	Focus molecules	Top diseases and functions	p–Value
	31	Post–translational modification	(1.49E–09 – 4.73E–03)
		Nervous system development and function	(1.16E–05 – 4.90E–02)
		Neurological disease	(1.16E–05 – 4.70E–02)
	31	Cardiac Inflammation	(8.27E–06 – 5.24E–01)
		Cardiovascular disease	(8.27E–06 – 5.32E–01)
		Inflammatory disease	(8.27E–06 – 2.23E–01)
	28	Lipid metabolism	(4.27E–07 – 4.62E–02)
		Molecular transport	(4.27E–07 – 4.62E–02)
		Small molecule biochemistry	(4.60E–06 – 4.73E–02)
	27	Embryonic development	(4.00E–05 – 1.95E–01)
		Nervous system development and Function	(4.00E–05 – 2.62E–02)
		Organ development	(4.00E–05 – 4.01E–01)
	26	Cell morphology	(4.16E–04 – 4.26E–02)
		Cellular assembly and organization,	(4.16E–04 – 4.72E–02)
		Hereditary disorder	(5.61E–04 – 1.05E–02)