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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Curr Stem Cell Rep. 2016 Oct 29;2(4):388–397. doi: 10.1007/s40778-016-0069-x

Figure 3. Activation of TGFβ signaling and its role in HSC function.

Figure 3

TGFβ is secreted as an inactive complex bound to latency-associated peptide (LAP) and the latent TGFβ 1 binding protein-1 (LTBP1) by megakaryocytes. Non-myelinated Schwann cells contribute to releasing the biologically active form of TGFβ from the latent complex. Active TGFβ can exert multiple functions on HSC and progenitors, including quiescence, proliferation, differentiation, and perhaps fate decisions.