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. 2017 Apr 27;23(6):946–955. doi: 10.1097/MIB.0000000000001131

FIGURE 4.

FIGURE 4.

GO profiling from RNA-seq data for thiopurine-treated patients: (A) biological processes significantly associated with genes underexpressed as a consequence of LDAA therapy; (B) sampled (jack-knife: each patient excluded in turn) data, biological processes significantly associated with underexpressed genes in LDAA-treated patients which were common to all subsampled sets; (C) biological processes significantly associated with over-expressed genes in LDAA-treated patients; (D) biological processes significantly associated with overexpressed genes which were common to all subsampled sets of LDAA-treated patients; in A to D, the BH FDR was set to P < 0.001 for GO categories. E, GO profiling from RNA-seq data for AZA-treated patients, showing biological processes significantly associated with underexpressed genes (BH FDR was set to P < 0.05 for GO categories). No biological processes were significantly associated with increases in gene expression in response to AZA, but only the GO cell compartments “cell periphery” and “plasma membrane,” were significantly associated with increases in gene expression in response to AZA and these were common to all subsamples.