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. 2017 May 11;10:2527–2538. doi: 10.2147/OTT.S134551

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© 2017 Zhou et al. This work is published and licensed by Dove Medical Press Limited

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Effect of XIAP knockdown on ESCC radiosensitivity.

Notes: (A) Radiosensitization by expression of XIAP was based on clonogenic cell survival assays. Stably transfected TE10 and TE11 were exposed to various doses of radiation prior to plating for clonogenic cell survival. (B) Flow cytometric analysis of apoptosis in stably transfected TE10 and TE11 cells treated with (6.0 Gy) or without irradiation. (C) Western blot of c-caspase-3, total caspase-3, cleaved c-PARP, and total PARP in stably transfected TE10 and TE11 cells with or without irradiation (6.0 Gy). GAPDH was used as an internal control. Each experiment was performed at least in triplicate. *P<0.05 and **P<0.01 vs control.

Abbreviations: XIAP, X-linked inhibitor of apoptosis protein; ESCC, esophageal squamous cell carcinoma.