Table 1. The suppressive effects of zacopride pretreatment or post-treatment on acute ischemic arrhythmias in anesthetized rats in vivo (mean ± SEM).
n | Arrhythmia latency time (s) | Total episodes of PVC | Duration of VT (s) | Incidence of VT (%) | Duration of VF (s) | Incidence of VF (%) | |
---|---|---|---|---|---|---|---|
Pretreatment | |||||||
Control | 8 | 344.1 ± 21.1 | 149 ± 23 | 51.2 ± 16.1 | 100 | 6.9 ± 2.5 | 75 |
Zac 5 μg/kg | 8 | 394.3 ± 18.2 | 157 ± 13 | 40.4 ± 5.2 | 100 | 0.7 ± 0.7 ** | 12.5 * |
Zac 15 μg/kg | 8 | 475.6 ± 35.0 ** | 45 ± 15** | 2.1 ± 1.4** | 25** | 0 ** | 0 ** |
Zac 50 μg/kg | 8 | 402.6 ± 36.7 | 38 ± 12** | 9.2 ± 2.9** | 75 | 0.2 ± 0.2 ** | 12.5 * |
Lidoc 7.5 mg/kg | 8 | 518.8 ± 27.8 **# | 57 ± 17**# | 1.2 ± 0.9**# | 25**# | 0.2 ± 0.2 **# | 12.5 *# |
Post-treatment | |||||||
Control | 8 | 335.6 ± 11.8 | 105 ± 18 | 51.9 ± 12.3 | 100 | 4.4 ± 1.7 | 75 |
Zac 15 μg/kg | 8 | 447.1 ± 26.1 ** | 14 ± 5** | 1.8 ± 0.9** | 37.5* | 0 ** | 0** |
Lidoc 7.5 mg/kg | 8 | 430.6 ± 20.9**# | 53 ± 19**# | 1.8 ± 1.0**# | 50# | 0.3 ± 0.3 **# | 12.5 *# |
PVC, premature ventricular contraction. VT, ventricular tachycardia. VF, ventricular fibrillation. Zac, zacopride. Lidoc, lidocaine. Duration of VT, mean episode duration of VT. Duration of VF, mean episode duration of VF.
* P < 0.05,
** P < 0.01 vs. control.
# P > 0.05 vs. 15 μg/kg Zac.