Table 1.

Comparison of commonly available products to treat opioid dependence

Drugs	Active ingredients	Administration	Average dosage/target range	Half-life
Revia®, Depade®	Naltrexone	Oral (tablet)	50 mg, 1×/day	13 hours45
Vivitrol® XR	Naltrexone	IM	380 mg, 1×/month	5–10 days59
Methadose®, Diskets®, Dolophine®	Methadone HCl	Oral (dispersible tablet in liquid), IM	2:1 (parental-to-oral ratio), 80–120 mg oral60	8–59 hours61
Xtampza® ER	Oxycodone HCl	Oral (capsule)	9–36 mg, 2×/day62	5.6 hours63
Narcan®	Naloxone HCl	Nasal spray	4 mg, 1 spray33	0.5–1.35 hours64
Suboxone®	Buprenorphine/naloxone	Oral (SL) tablet, buccal (film)	4/1 mg, 8/2 mg, 12/3 mg62	24–42 hours/2–12 hours65
Bunavail®	Buprenorphine/naloxone	Buccal (film)	2.1/0.3 mg, 4.2/0.7 mg, 6.3/1 mg66	16.4–27.5 hours/1.9–2.4 hours67
Zubsolv®	Buprenorphine/naloxone	Oral (SL) tablet	Two 5.7 mg/1.4 mg tablets 1×/day (11.4 mg/2.8 mg)68	24–48 hours/2–12 hours65
Probuphine®	Buprenorphine HCl	Subdermal implant	Four implants deliver equivalent to daily doses <8 mg suboxone55	24–48 hours55

Abbreviations: IM, intramuscular; IV, intravenous; SL, sublingual.