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. 2017 May 11;10:1125–1134. doi: 10.2147/JPR.S131104

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© 2017 Moon and Park. This work is published and licensed by Dove Medical Press Limited

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Spontaneous neuronal activity in the ZI in sham-treated and CCI rats.

Notes: (A) ZI is shown in the schematic diagram of a coronal section. (B) Overall thalamic neuronal activity in sham-treated and CCI rats. (C) Injection of high concentrations of GABA_A agonist and antagonist into the ZI changed the firing rate (spikes/s) for 30 min in sham-treated animals. (D) Firing rate increased after injection of GABA agonist in CCI rats. PSTH shows firing rate as time progresses after injection of GABA_A agonist (E) and GABA_A antagonist (F) in CCI rats. In total, 12 rats were used in the current analysis. One-way ANOVA was used to compare each data point with saline-baseline. *P<0.05. Sham-treated (n=6); CCI (n=6).

Abbreviations: ANOVA, analysis of variance; CCI, chronic constriction injury; GABA, gamma-aminobutyric acid; PSTH, peristimulus time histogram; ZI, zona incerta.