Table 2.

Comparison of MTHFR677C > T genotypes and alleles between the study cohort and controls.

MTHFR677C > T	Patients n = 89, % (95% CI)	Controls n = 400, % (95% CI)	Unadjusted-OR (95% CI)	p-Value
Genotypes
CC	72 (80.9; 71–88)	184 (46.0; 41–51)		< 0.0001
CT	8 (8.9; 4–17)	159 (39.8; 35–45)
TT	9 (10.1; 5–18)	57 (14.2; 11–18)
CC + CT : TT	80 (89.9; 81–95):9 (10.1; 5–18)	343 (85.8; 82–89):57 (14.2; 11–18)	0.68 (0.32–1.42)	0.39
CC:CT + TT	72 (80.9; 71–88):17 (19.1; 12–29)	184 (46.0; 41–51):216 (54.0; 49–59)	0.20 (0.11–0.35)	< 0.0001
Alleles
C	152 (85.4; 79–90)	527 (65.9; 62–69)	0.33 (0.21–0.51)	< 0.0001
T	26 (14.6; 10–21)	273 (34.1; 31–37)

Two-sided 95% CI for the single proportion includes continuity correction.