Table 3.

Comparison of MTHFR 1298A > C genotypes and alleles between the study cohort and controls.

MTHFR 1298A > C	Patients n = 89, % (95% CI)	Controls n = 40, % (95% CI)	Unadjusted-OR (95% CI)	p-Value
Genotypes
AA	41 (46.1; 36–57)	251(62.7; 58–67)		0.03
AC	43 (48.3; 37–59)	138 (34.5; 30–39)
CC	1 (1.1; 0.2–6)	11 (2.8; 1.5–5)
Unknown	4 (4.5; 1.5–11)
AA + AC:CC	84 (94.4; 87–98):1 (1.1; 0.2–6)	389 (97.2; 95–98):11 (2.8; 1.5–5)	0.42 (0.05–3.30)	0.49
AA: AC + CC	41 (46.1; 36–57):44 (49.4; 39–60)	251 (62.7; 58–67):149 (37.3; 32–42)	1.81 (1.13–2.90)	0.0182
Alleles
A	124 (73.0; 65–79)	640 (80.0; 77–82)	1.48 (1.01–2.17)	0.05
C	46 (27.0; 20 – 34)	160 (20.0; 17–23)
Combined heterozygosity
1298AC + 677CT	2 (2.2; 0.4–8)	48 (12.0; 9–15)	0.18 (0.04–0.74)	0.0139
Combined genotypes
1298AA/677CC: 1298AC + CC/677CT + TT	27 (32.0; 22–43): 5 (5.6; 2–13)	N/A

N/A, not available. Combined heterozygosity and genotypes also shown. Two-sided 95% CI for the single proportion includes continuity correction.