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. Author manuscript; available in PMC: 2017 May 18.
Published in final edited form as: Drug Metab Pers Ther. 2017 Mar 1;32(1):23–32. doi: 10.1515/dmpt-2016-0039

Table 6.

Average metrics (overall and by carrier status) of blood levels corresponding to relevant DPN-related biochemical markers in a sub-set of the study cohort (i.e. n = 59 Puerto Rican patients with T2DM) and association analyses between these biochemical markers and the combinatorial MTHFR677C > T and 1298A > C haplotypes (last two columns).

Biomarkers Total Wild types (WT) Carriers Odds ratio (OR), 95% CI p-Value
HbA1C, % 7.60 ± 1.07 7.31 ± 0.87 7.75 ± 1.12 3.9 (0.77–19.72) 0.09
Vitamin B12, pg/mL 454.34 ± 310.6 488.29 ± 408.59 432.44 ± 273.5 2.22 (0.57–8.65) 0.25
Folate, ng/mL 18.97 ± 3.43 19.36 ± 3.31 18.84 ± 3.78 1.89 (0.51–6.96) 0.33
Hcy, μM 11.84 ± 5.13 11.6 ± 3.88 12.09 ± 6.04 0.82 (0.25–2.58) 0.73

χ2 or Fisher’s exact tests were used for the association analyses. Odd ratios and 95% CI were calculated. Values a given as mean ± SD. HbA1C, glycosylated hemoglobin; Hcy, homocysteine.