Figure 1.

Proposed mechanisms of induction of inflammation-mediated EMT and its subsequent effects on PDAC chemoresistance and progression, which eventually end up in poor survival rates in patients with PDAC. In this figure, we show that protumor inflammation can shift the balance and transform the epithelial cells toward mesenchymal phenotype. These newly gained mesenchymal traits promote tumor invasion and resistance to chemotherapy leading to bad prognosis. CAFs indicates cancer-associated fibroblasts; EMT, epithelial-mesenchymal transition; PDAC, pancreatic ductal adenocarcinoma.