. 2017 May 18;12(5):e0177934. doi: 10.1371/journal.pone.0177934

Table 1. Effects of somatostatin analogs on food intake, body weight, wet kidney weight.

	CONT	OCT	PAS	OCT/PAS
Food intake (g/day)	21.5 ± 2.6	21.3 ± 1.6	19.1 ± 5.0	19.2 ± 3.4
Body weight (g)	496 ± 18	492 ± 43	412 ± 42 ^, ^$ $**	411 ± 45 ^, ^$ $**
Wet kidney weight (g)	7.10 ± 1.64	6.59 ± 1.20	4.13 ± 0.67 ^, ^$ $**	4.18 ± 0.50 ^, ^$ $**

Male PCK rats were assigned randomly to 4 groups (n = 6 per each): treated with 8 mg/kg octreotide long-acting release alone (OCT), 8 mg/kg pasireotide long-acting release alone (PAS), co-application of both (OCT/PAS), or vehicle (microparticles liquid; CONT) from 4 to 16 weeks of age. Food intake (g/day), body weight (g) and wet kidney weight (g) are shown. The parameters are expressed as mean ± SD. Difference between CONT and each drug-treated group

**: P < 0.01. Comparison between OCT and PAS or OCT/PAS

$ $: P < 0.01. There was no statistically significant difference between the PAS and OCT/PAS groups in each measurement.