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. 2017 May 18;13(5):e1006339. doi: 10.1371/journal.ppat.1006339

Fig 12. Model for regulation of gene expression by TprA2-PhrA2.

Fig 12

(A) In the OFF state, TprA2 inhibits gene expression. (B) In the ON state, PhrA2 releases TprA2-mediated gene inhibition. This effect of PhrA2 is observed from synthetic peptide added to the extracellular milieu and cell-free supernatant, suggesting that PhrA2 is exported, activated and re-imported before it modulates TprA2 activity, in both the producer PMEN1 cells and surrounding PMEN1 population. (C) PhrA2 secreted by PMEN1 cells activates gene expression of tprA and associated lanA, in both PMEN1 and non-PMEN1 cells. Red circular shape/TprA2, purple triangle/PhrA2, blue circular shape/TprA; blue triangle/PhrA.