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. Author manuscript; available in PMC: 2017 May 18.
Published in final edited form as: Brain Res Bull. 2016 Apr 28;126(Pt 2):199–206. doi: 10.1016/j.brainresbull.2016.04.019

Fig. 2.

Fig. 2

Gamma-secretase is composed of four essential subunits: presenilin (PS1), Nicastrin (Nct), Pen-2, and APH-1. Presenilin must be endoproteolysed into the N and C terminal fragments to become active, and the catalytic residues (D*) are present in this subunit.