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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Twin Res Hum Genet. 2016 Jun 15;19(4):341–350. doi: 10.1017/thg.2016.46

Table 3.

Bivariate analyses for broad migraine and broad depression with and without sex-limitation based on two-threshold model

Disorders Total sample Sex-limitation
Female Male
A E A E A E
Broad migraine^ 0.56 (0.53–0.60) 0.44 (0.40–0.47) 0.60 (0.55–0.64) 0.40 (0.36–0.45) 0.49 (0.41–0.56) 0.51 (0.44–0.59)
Broad depression^ 0.42 (0.37–0.47) 0.58 (0.53–0.63) 0.44 (0.38–0.50) 0.56 (0.50–0.62) 0.40 (0.31–0.48) 0.60 (0.52–0.69)
Bivariate variance 0.055 (0.036–0.078) 1.5×10−3 (3.4×10−6–7.1×10−3) 0.047 (0.026–0.074) 4.1×10−6 (4.1×10−6–4.2×10−6) 0.058 (0.024–0.11) 7.3×10−3 (2.1×10−5–0.028)
Correlation 0.36 (0.29–0.43) 0.050 (−0.011–0.11) 0.32 (0.25–0.41) 2.7×10−3 (−0.075–0.080) 0.38 (0.25–0.52) 0.11 (5.4×10−3–0.21)

A: additive genetic factors; E: unique environmental factors.

^

Three phenotype categories for broad migraine: non-migraine, self-report/ID migraine and IHS MO/MA; three phenotype categories for broad depression: non-depressed, MiDD and MDD.