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. Author manuscript; available in PMC: 2017 Nov 18.
Published in final edited form as: Oncogene. 2016 Dec 12;36(20):2868–2878. doi: 10.1038/onc.2016.440

Figure 5. KPNA4 knockdown blocks bone metastasis of prostate cancer.

Figure 5

(a–b) Luciferase-labeled PC3 sh-scramble or shKPNA4 cells (1×106) were intracardiacly injected into the left ventrical of nude mice, bioluminescence imaging of the bone metastatic lesion was taken after 4 weeks post injection, *p<0.05. (c) H&E staining showing the metastatic lesions in the hind limbs. CD206 positive M2 TAMs infiltration in (d) primary tumor tissue or (e) bone marrow was determined by immunofluorenscence staining. DAPI was used as an indicator of nucleus.