Table 2.
Properties of the microcirculation before and after the sublingual topical application of acetylcholine and nitroglycerin, as measured using manual video analysis and algorithm-based video analysis
| Native | Acetylcholine | Nitroglycerin | p | |
|---|---|---|---|---|
| TVD (manual) [mm/mm2] |
14.81 ± 0.65 | 15.72 ± 0.49 | 20.32 ± 0.50a, b | <0.0001 |
| Space-time diagram-based venular flow velocity [μm/s] | 242 ± 21 | 358 ± 62 | 496 ± 22a | <0.01 |
| TVD (algorithm-based) [mm/mm2] |
18.80 ± 0.61 | 18.69 ± 0.66 | 21.06 ± 0.57a, b | <0.01 |
| APSI [1] | 1.33 ± 0.06 | 1.43 ± 0.08 | 1.64 ± 0.08a | 0.02 |
Values are given as mean ± SEM. Pairwise analysis is represented by a, b where p < 0.05 versus nativea, and acetylcholineb. Analysis was performed in n = 41 subjects for TVD (manual), TVD (algorithm-based) and APSI, and in n = 23, n = 27, and n = 14 subjects in the native, acetylcholine, and nitroglycerin condition for space-time diagram-based venular flow velocity, respectively
TVD total vessel density, APSI average perfused speed index