Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 May 18;7:2063. doi: 10.1038/s41598-017-02275-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The effect of SNP on membrane potential and capsaicin-induced inward current (Icap) in cultured NG neurons. (a) Representative membrane potential traces of the NG neurons after administration of SNP (0.16 mM), or co-application of SNP and NEM (5 mM) or ODQ (10 µM). The filled bars on the trace represent the administration of corresponding drugs. (b) Summary values show that application of SNP (0.16 mM) depolarized the membrane potential of NG neurons gradually. CZP (50 µM) or NEM (5 mM) blocked the effect of SNP, while ODQ (10 µM) had no effect. n = 7 in each column, *P < 0.05 vs vehicle, ^# P < 0.05 vs SNP group, ^## P < 0.01 vs SNP group, Dunn’s post hoc test after a one-way ANOVA. (c) Representative traces of Icap after incubation of SNP (0.16 mM), or co-application of SNP and NEM (5 mM) or ODQ (10 µM). NEM eliminated the activation of Icap caused by SNP. Open bars on the trace represent the application of capsaicin for 60 s, and the filled bars indicate the pretreatment of corresponding drugs. (d) Summary values show that administration of SNP (0.16 mM) increased Icap. This effect was abolished by NEM, but not ODQ. n = 7 in each column, *P < 0.05 vs vehicle, ^## P < 0.01 vs SNP group, Dunn’s post hoc test after a one-way ANOVA.