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. 2017 May 18;7:2099. doi: 10.1038/s41598-017-02296-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PSAT1 expression associated genes in the gene expression dataset. The 155 tumors in the Affymetrix cohort were stratified according to PSAT1 expression. All genes were annotated for KEGG terms and Global test was performed to assess which terms were associated to PSAT1 expression. Panel A and B display the top 2 KEGG pathways associated to PSAT1: Cytokine-cytokine receptor interaction (A) and Jak-STAT signaling pathway (B). Bar charts (left) represent enriched genes in each pathway, with red and green columns representing the association to high and low expression of PSAT1, respectively. Heatmaps of most significantly enriched genes in each pathway (enrichment statistic P < 0.01; genes are ordered based on decreasing average expression) in relation to PSAT1 expression are also shown (right).