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. 2017 May 18;7:2102. doi: 10.1038/s41598-017-02055-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of truncated derivatives of FELIAP as inhibitors of FXIa-mediated amidolysis. (A) Extent of truncation analysis. Sequences to the left of bolded lines crossing the Mfold-generated predicted secondary structure of FELIAP are identified as FELIAP_X, where X = the length of the truncated aptamer (32, 38, 42, 49, 55, 64, or 74 for full-length FELIAP. (B) Tabular depiction of truncated aptamers relative to FELIAP; for instance, FELIAP_32 (relative sequence 22–53) is identical to FELIAP except for the deletion of 21 nucleotides from the 5′end and 21 nucleotides from the 3′ end of FELIAP. (C) Means ± SEM (n = 3) of colour generation following FXIa-mediated amidolysis of chromogenic substrate S2366, in the presence (black bars) of SCRAPT, FELIAP, or truncated derivatives of FELIAP identified in panels A and B, or in the absence of of added DNA molecules (white bar).