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. 2017 May 18;7:2108. doi: 10.1038/s41598-017-01108-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Temperature increase profiles in SCC7 tumor tissue after in vivo photothermal treatment. (A) Infrared photothermal images of mice measured after tail vein injection and laser irradiation. (a) Mice injected with 200 µL PBS plus further laser irradiation, (b) Mice injected with 200 µL MHI-DSPE-SPION at 10 mg[Fe]/kg concentration in PBS plus further laser irradiation. (B) (a) Maximum temperature profiles of SCC7 subcutaneous tumors after tail vein post-injection plus further laser irradiation and (b) Temperature change of tumor area upon laser irradiation. *P < 0.05 relative to PBS injected group (n = 3).