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. 2017 May 18;7:2098. doi: 10.1038/s41598-017-02197-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Canonical Pathway of ‘CREB Signaling in Neurons’ (IPA, p-value 3.02E-05). Color red: the darker, the more damaging mutations were found by exon sequencing. Color pink: overlap of genes within dataset of 282 damaging mutations. Color pink double bordered: shows more than one gene within a complex. Genes from the dataset involved in the pathway are: PRKDC, NRAS, TYK2, CREBBP, PIK3C2G, ATR, JAK2, PRKD3, ATM.

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