Table2.

Univariate and multivariate analysis with negative binomial regression comparing the mutation counts by variables in patients with lung adenocarcinoma (n = 85).

Variable	No. of patients (n = 85)	No. of missense mutation median(range)	Univariate analysis p value	Multivariate analysis p value
Age, year			0.765	0.897
≤65	59	48 (3–787)
>65	26		80.5 (19–236)
Gender			<0.0001	0.0002
Male	52	92 (16–787)
Female	33	34 (3–207)
Smoking			<0.0001	0.0310
Yes	33	126 (16–787)
No	47	46 (3–262)
NA	5	—
Stage
I	18	39.5 (3–787)	(reference)	(reference)
II	16	74.5 (20–262)	0.879	0.3340
III	45	59 (16–690)	0.332	0.0940
IV	6	50.5 (37–144)	0.43	0.6670
NA		—
COPD			0.0211	0.6560
Yes	18	88.5 (19–690)
No	67	51.0 (3–787)

NA, Not applicable.