Table 4.

Performance indicators and the evaluation method of some carcinogenicity classification models reported in the literature.

Model name	Evaluation method	Q (%)	SE (%)	SP (%)	Reference
MC4PCa	10-fold CVe	66.5	61.4	70.9	14
MDL-QSARb	10-fold CV	69.2	62.8	74.8	14
lazar	LOOCVf	66.9	59.9	73.4	15
Naïve Bayesian	5-fold CV	68	57	79	16
CP ANN MDLc	5-fold CVg	66	—	—	12
CP ANN Dragon (VEGA CAESAR)c	5-fold CV	62	—	—	12
VEGA IRFMN/Antares	5-fold CV	66.0	83.1	48.3	29
VEGA IRFMN/ISSCAN-CGXd	5-fold CV	72.7	76.5	61.8	29

^aThe coverage of this model was 96%. ^bThe coverage of this model was 97%. ^cThis study did not provide the SE and SP of the models. ^dThis model was trained using carcinogenesis data from both rats and mice. ^eTen-fold cross-validation. ^fLeave-one-out cross-validation. ^gFive-fold cross-validation.