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. 2017 May 18;7:2137. doi: 10.1038/s41598-017-02337-4

Figure 1.

Figure 1

Effect of the timing of intramuscular administration of obestatin following muscle injury. (a) A schematic diagram of the muscle injury and regeneration experiment. (b) Tibialis anterior (TA) muscle weight after 30 days of treatment with vehicle or obestatin at 300 nmol/kg body weight each 72-, 168- or 360-h. Muscle weights were normalized by body weights and expressed as percent changes from uninjured control. Data are shown as mean ± SEM of 5 animals per group (*,#,&P < 0.05 versus control values). (c) Cross sectional area of muscle fibers from TA muscles after intramuscular injection of obestatin [300 nmol/kg body weight each 72-, 168 or 360-h; n = 5 per group] at 30 days. Data are shown as mean ± SEM of 5 animals per group (*,#,&P < 0.05 versus control values). (d) Effect of intramuscular injection of obestatin [300 nmol/kg body weight each 72-, 168 or 360-h; n = 5 per group] on twitch force at 30 days following injury (*,#,&P < 0.05 versus control values). (e) Effect of intramuscular injection of obestatin [300 nmol/kg body weight each 72-, 168 or 360-h; n = 5 per group] on tetanic force at 30 days following injury. Data in c and d are expressed as mean ± SEM (*,#,&P < 0.05 versus control values).