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. 2017 May 18;7:2091. doi: 10.1038/s41598-017-02286-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of GR blockade on nocturnal expression of AA-NAT and ASMT coding genes and plasma levels of melatonin of rats killed at ZT18. Mifepristone-treated animals showed lower circulating melatonin levels and reduced pineal expression of Aanat levels at ZT18. N = 5–8 animals per group. The graphs show the mean ± SEM. Means were compared by Student’s t test.