Table 2.
Imaging measure characteristics in the contralateral breast for 51 breast cancer cases and 51 controls matched by age and year-of-MRI scan.
| Imaging metrics | Cancer cases (n = 51) | Controls (n = 51) | P-value |
|---|---|---|---|
| Mammographic density (visual BI-RADS density categories): # of subjects (%) | 0.45 | ||
| Fatty | 2 (4%) | 1 (2%) | — |
| Scattered fibroglandular density | 14 (27% | 13 (25%) | — |
| Heterogeneously dense | 32 (63%) | 33 (65%) | — |
| Extremely dense | 3 (6%) | 4 (8%) | — |
| |FGT| (unit cm3): mean ± SD (range) | 126 ± 88 (38–442) | 117 ± 79 (24–524) | 0.58 |
| FGT% (%): mean ± SD (range) | 13 ± 8 (5–40) | 14 ± 7 (4–36) | 0.59 |
| |BPE| (unit cm3): mean ± SD (range) | |||
| SUB1 | 494 ± 333 (135–1814) | 358 ± 183 (84–1004) | 0.014 |
| SUB2 | 639 ± 415 (149–2173) | 466 ± 246 (95–1161) | 0.014 |
| SUB3 | 685 ± 436 (168–2308) | 510 ± 274 (93–1243) | 0.020 |
| BPE% (%): mean ± SD (range) | |||
| SUB1 | 45 ± 9 (21–62) | 40 ± 11 (18–62) | 0.011 |
| SUB2 | 58 ± 11 (31–78) | 51 ± 13 (23–77) | 0.006 |
| SUB3 | 62 ± 11 (36–82) | 56 ± 14 (28–80) | 0.014 |
FGT = Fibroglandular tissue.
BPE = Background parenchymal enhancement.
SUB1, SUB2, SUB3 = Subtraction sequence (i.e., post-contrast – pre-contrast) for each of first, second, and third post-contrast sequences, respectively.
*Shown BPE and FGT measure summaries are from the contralateral negative breast of both cancer cases and controls. The p-values are for comparison of controls to cancer cases using paired t-test.