Table 3.
Breast cancer odd ratios for BPE quantified separately from three SUBs for 51 women with a cancer diagnosis and 51 controls with a biopsy-proven benign finding.
| SUB1 | SUB2 | SUB3 | ||
|---|---|---|---|---|
| Comparison A: Contralateral breasts of both cancer cases and controls | ||||
| |BPE| | Univariate | 1.5 (1.1, 2.2); p = 0.026 | 1.4 (1.0, 1.8); p = 0.025 | 1.3 (1.0, 1.7); p = 0.031 |
| Multivariable | 2.0 (1.1, 3.7); p = 0.021 | 1.9 (1.1, 3.0); p = 0.014 | 1.8 (1.1, 2.8); p = 0.017 | |
| BPE% | Univariate | 3.1 (1.2, 7.9); p = 0.018 | 2.5 (1.2, 5.3); p = 0.012 | 2.3 (1.1, 4.5); p = 0.021 |
| Multivariable | 3.5 (1.3, 9.8); p = 0.015 | 2.9 (1.3, 6.6); p = 0.010 | 2.5 (1.2, 5.1); p = 0.015 | |
| Comparison B: Benign breast of controls vs contralateral breasts of cancer cases | ||||
| |BPE| | Univariate | 1.5 (1.0, 2.1); p = 0.037 | 1.4 (1.0, 1.8); p = 0.031 | 1.3 (1.0, 1.7); p = 0.038 |
| Multivariable | 2.3 (1.1, 4.8); p = 0.032 | 1.9 (1.1, 3.4); p = 0.020 | 1.8 (1.1, 3.1); p = 0.028 | |
| BPE% | Univariate | 7.0 (1.6, 30.5); p = 0.010 | 4.7 (1.6, 13.7); p = 0.005 | 3.3 (1.2, 9.1); p = 0.023 |
| Multivariable | 7.4 (1.6, 35.6); p = 0.012 | 5.5 (1.7, 18.4); p = 0.005 | 3.5 (1.2, 10.0); p = 0.020 | |
|BPE| = Volume of background parenchymal enhancement, with odds ratio for 200 cm3 difference.
BPE% = Percentage of background parenchymal enhancement volume (|BPE|) relative to breast volume, with odds ratio for 20 percentage point difference.
SUB1, SUB2, SUB3 = Subtraction sequence (i.e., post-contrast – pre-contrast) for each of first, second, and third post-contrast sequences, respectively.
Odds ratios, 95% confidence intervals, and p-values are shown for univariate conditional logistic regression, and for multivariable models controlling for menopausal status, family history of breast cancer, BI-RADS-based mammographic density, |FGT|, and FGT%. The p-values indicate statistical significance of the tested BPE measure (i.e., |BPE| or BPE%) in the logistic regression modeling. The p-values shown in the table were prior to the multiple test adjustment by FDR. After applying the adjustment for 6 comparisons at the 0.05 overall FDR, the 6 adjusted p-values remained statistically significant (all p < 0.031 for the 6 univariate analyses in Comparison A; all p < 0.021 for the 6 multivariable analyses in Comparison A; all p < 0.038 for the 6 univariate analyses in Comparison B; all p < 0.032 for the 6 multivariable analyses in Comparison B).