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. 2017 May 19;11:145. doi: 10.3389/fncel.2017.00145

Figure 5.

Figure 5

GR agonist Dex eliminated the OB-induced attenuation of mechanical allodynia and thermal hyperalgesia of neuropathic pain. Intrathecal administration of Dex (4 μg per rat, daily for 1 week) exacerbated down-regulation of mechanical PWT (A) and thermal PWL (B) in Dex-NOB-SNL rats compared with those in Veh-NOB-SNL rats and induced significantly lower mechanical PWT and thermal PWL in the Dex-OB-SNL group than those in the Veh-OB-SNL group. The nociceptive behaviors of NOB-Sham rats and OB-Sham rats were not affected by Dex intrathecal administration. **p < 0.01, ***p < 0.001 vs. corresponding NOB-Sham groups; ###p < 0.001 vs. corresponding OB-Sham groups; $$p < 0.01, $$$p < 0.001 vs. corresponding NOB-SNL groups; &&&p < 0.001 vs. corresponding vehicle groups; n = 7 per group.