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. 2017 May 19;11:145. doi: 10.3389/fncel.2017.00145

Figure 7.

Figure 7

GR agonist Dex regulated brain-derived neurotrophic factor (BDNF), TrkB and N-methyl-D-aspartate (NMDA) receptor NR2B subunit expression in the spinal dorsal horn of rats with depression and neuropathic pain. Intrathecal administration of Dex (4 μg per rat, daily for 1 week) exacerbated the enhancement of spinal BDNF (A), TrkB (B) and NR2B (C) expressions in the Dex-NOB-SNL group compared to the Veh-NOB-SNL group and induced significant up-regulation of these proteins in the Dex-OB-SNL group compared to those in the Veh-OB-SNL group. The protein expression levels of NOB-Sham rats and OB-Sham rats were not affected by Dex. *p < 0.05, ***p < 0.001 vs. corresponding NOB-Sham groups; #p < 0.05, ###p < 0.001 vs. corresponding OB-Sham groups; $p < 0.05, $$p < 0.01, $$$p < 0.001 vs. corresponding NOB-SNL groups; &&p < 0.01, &&&p < 0.001 vs. corresponding vehicle groups; n = 5–6 per group.