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. 2017 May 19;10:144. doi: 10.3389/fnmol.2017.00144

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Copyright © 2017 He, Liu, Zhang, Liang, Dai, Zeng, Pei, Xu and Lan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of voluntarily running on the activation of astrocytes and microglia. (A) Immunofluorescent staining of glial fibrillary acidic protein (GFAP)-positive astrocytes in the control and running groups (200×, scale bar = 100 μm). (B) Histogram comparing the numbers of GFAP-positive astrocytes in the cortex and hippocampus (n = 6 per group). (C) Immunofluorescent staining of ionized calcium-binding adapter molecule 1 (IBA1)-positive microglia in the control and running groups (200×, scale bar = 100 μm). (D) Histogram comparing the numbers of IBA1-positive microglia in the cortex and hippocampus (n = 6 per group). Datasets are expressed as means ± SD, n = 6. *P ≤ 0.05; ***P ≤ 0.001.