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. 2017 May 19;11:248. doi: 10.3389/fnins.2017.00248

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Copyright © 2017 Gorenberg and Chandra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hsc70/DNAJ co-chaperone cycle. 1. Free clients or those recruited by DNAJ bind Hsc70-ATP. 2. DNAJ stimulates Hsc70's ATPase activity. 3. An Hsc70 nucleotide exchange factor (NEF) binds Hsc70-ADP. 4. NEF stimulates ADP-ATP exchange. 5. Hsc70-ATP releases the client and enters a new round of chaperone activity.