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Auxilin is an Hsc70 co-chaperone for clathrin uncoating. (A) Cartoon depicts structure of a clathrin triskelion. Three clathrin ankle segments cross to form a stable clathrin cage. (B) Assembled clathrin coat containing clathrin heavy chain and clathrin light chain, as determined by electron microscopy (PDB:3IYV; Fotin et al., 2004b). (C) The J domain of auxilin (shades of blue) interacts with the clathrin coat (shades of red and yellow; PDB: 1XI5; Fotin et al., 2004a).
