Table 2.
Relationship between blood pressure levels at baseline and re-examination and dementia risk
| Characteristic | HR, 95% CIa (per 10 mmHg) | p value |
|---|---|---|
| Baseline supine SBP (n = 17,912) | 1.04 (0.98–1.10) | 0.19 |
| Baseline supine DBP (n = 17,909) | 1.05 (0.95–1.16) | 0.30 |
| Orthostatic SBP reaction (n = 17,884) | 1.02 (0.89–1.15) | 0.74 |
| Orthostatic DBP reaction (n = 17,875) | 1.22 (1.01–1.44) | 0.036 |
| Orthostatic hypotensionb (383/17,492) | 1.18 (0.73–1.89) | 0.51 |
| Re-examination SBP (n = 18,044) | 0.94 (0.89–0.99) | 0.011 |
| Re-examination DBP (n = 18,043) | 0.87 (0.78–0.96) | 0.006 |
| SBP decrease between baseline and re-examination (n = 17,719) | 1.07 (1.03–1.12) | 0.002 |
| DBP decrease between baseline and re-examination (n = 17,715) | 1.16 (1.08–1.25) | <0.001 |
HR hazard ratio, CI confidence interval, SBP systolic blood pressure, DBP diastolic blood pressure
aAdjusted for age, gender, anti-hypertensive treatment, smoking, diabetes, prevalent cardiovascular disease, and plasma-cholesterol
bOrthostatic hypotension is a categorical variable