Fig. 3.

Functional changes of human serum albumin (HSA) with the progression of liver disease a 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging ability of purified HSA. b Antioxidant potential of plasma—biological antioxidant potential (BAP) test. c Levels of oxidative stress metabolites in the plasma—derivative of reactive oxygen metabolites (d-ROMs) test. d Unbound fraction of ketoprofen to purified HSA. Values are expressed as the mean ± standard deviation. Data were analyzed by a Jonckheere–Terpstra (JT) test and analysis of variance (ANOVA). P < 0.05 was considered to indicate a statistically significant difference. *P < 0.05, ANOVA. CH chronic hepatitis, CP-A Child–Pugh class A cirrhosis, CP-B Child–Pugh class B cirrhosis, CP-C Child–Pugh class C cirrhosis, U. CARR Carratelli units