Table 2.

Incidence trends for lung cancer histologic subtypes, Surveillance, Epidemiology, and End Results 17, excluding Alaska, by gender, 2000–2011.

Lung histologic subtype	Male				Female
	Rate	APC	APC 95% confidence interval	Period	Rate	APC	APC 95% confidence interval	Period
Total lung cancer	70.1	−2.0*	(−2.3 to −1.8)	2000–2009	46.7	−0.2*	(−0.3 to 0.0)	2000–2009
	61.7	−4.0*	(−6.9 to −1.0)	2009–2011	44.6	−3.7*	(−5.0 to −2.2)	2009–2011
Squamous cell carcinoma	18.1	−4.1*	(−5.3 to −2.9)	2000–2005	7.6	−1.8	(−3.6 to 0.0)	2000–2004
	16.7	0.7	(−0.2 to 1.6)	2005–2011	7.8	1.7*	(0.9 to 2.4)	2004−2011
Small cell carcinoma	8.8	−3.4*	(−3.9 to −2.9)	2000–2011	7.1	−1.7*	(−2.2 to −1.1)	2000–2009
					6.3	−6.1*	(−11.6 to −0.1)	2009–2011
Adenocarcinoma	23.4	−3.1*	(−4.3 to −2.0)	2000–2004	18.3	−0.7	(−0.7 to −1.9)	2000–2004
	23.4	1.8*	(1.3 to 2.3)	2004–2011	19.9	2.8*	(2.4 to 3.3)	2004–2011
Large cell	2.5	−11.8*	(−12.8 to −10.7)	2000–2011	1.8	−9.1*	(−9.9 to −8.3)	2000–2007
					1.0	−13.1*	(−15.6 to −10.5)	2007–2011
Other specified carcinomas	2.6	−9.0	(−20.7 to −4.3)	2000–2002	2.3	2.3*	(1.3 to 3.2)	2000–2011
	2.5	1.6*	(0.4 to 2.9)	2002–2011
Total malignant neoplasms and carcinoma unspecified	16.1	2.9	(−0.4 to 6.2)	2000–2005	9.5	4.6*	(1.2 to 8.2)	2000–2005
	14.0	−10.1*	(−16.5 to −3.2)	2005–2009	9.2	−8.2	(−20.7 to 6.2)	2005–2008
	8.9	−22.2*	(−35.7 to −5.9)	2009–2011	6.1	−18.9*	(−26.1 to −11.0)	2008–2011

APC, annual percent change.

*Change is significantly different from 0, p < 0.05.