Table 1.
Physiological, biochemical and hemodynamic parameters.
| Baseline | Reperfusion 5 min | Reperfusion 10 min | Reperfusion 20 min | Reperfusion 30 min | Reperfusion 60 min | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CP− | CP+ | CP− | CP+ | CP− | CP+ | CP− | CP+ | CP− | CP+ | CP− | CP+ | |
| ARI (ms) | 143 ± 4.29 | 137 ± 6.0 | 158 ± 5.4 | 132 ± 6.5* | 152 ± 4.1 | 144 ± 4.2 | 150 ± 5.4 | 140 ± 5.1 | 148 ± 5.3 | 136 ± 4.8 | 144 ± 5.5 | 143 ± 6.1 |
| TAT (ms) | 16.29 ± 1.81 | 17.13 ± 0.79 | 20.70 ± 1.32 | 18.00 ± 1.10 | 21.70 ± 2.05 | 17.79 ± 1.53* | 20.50 ± 1.09 | 16.25 ± 1.83* | 21.00 ± 1.84 | 16.05 ± 0.98* | 20.92 ± 2.10 | 16.05 ± 0.73* |
| cQT | 219 ± 6.5 | 217 ± 7.7 | 234 ± 8.7 | 241 ± 13.0 | 250 ± 7.8 | 231 ± 5.7* | 226 ± 6.1 | 213 ± 6.2 | 223 ± 5.6 | 217 ± 5.7 | 230 ± 6.2 | 220 ± 5.2 |
| PQ (ms) | 63 ± 2.0 | 58 ± 2.2 | 63 ± 4.0 | 59 ± 2.1 | 64 ± 3.7 | 61 ± 2.0 | 64 ± 2.5 | 60 ± 2.4 | 65 ± 2.1 | 63 ± 2.4 | 61 ± 2.7 | 65 ± 2.8 |
| QRS (ms) | 26 ± 0.71 | 26 ± 0.61 | 25 ± 0.46 | 25 ± 0.70 | 27 ± 0.97 | 24 ± 0.35 | 25 ± 0.43 | 24 ± 0.18 | 24 ± 0.47 | 24 ± 0.49 | 26 ± 0.75 | 24 ± 0.25 |
| BCL (ms) | 408 ± 8.9 | 396 ± 9.9 | 491 ± 48.7 | 312 ± 10.7* | 377 ± 10.6 | 382 ± 9.6 | 435 ± 11.2 | 447 ± 14.2 | 447 ± 20.7 | 388 ± 13.4 | 390 ± 12.2 | 421 ± 16.4 |
| HR (min−1) | 155 ± 3.5 | 155 ± 3.3 | 167 ± 4.0 | 192 ± 6.3* | 163 ± 4.6 | 161 ± 3.9 | 141 ± 3.7 | 140 ± 4.7 | 141 ± 5.0 | 156 ± 5.1 | 158 ± 4.4 | 151 ± 5.1 |
| CF/heart weight (ml/min/g) | 3.18 ± 0.11 | 3.20 ± 0.08 | 3.08 ± 0.16 | 3.31 ± 0.21 | 2.86 ± 0.13 | 3.17 ± 0.13 | 2.52 ± 0.11 | 3.03 ± 0.12 | 2.57 ± 0.12 | 2.98 ± 0.13 | 2.40 ± 0.06 | 2.86 ± 0.14 |
| Lactate (mmol/L) | 0 ± 0 | 0 ± 0 | 0.07 ± 0.02 | 0.05 ± 0.03 | 0.02 ± 0.01 | 0 ± 0 | 0.01 ± 0.02 | 0 ± 0 | 0.01 ± 0.02 | 0 ± 0 | 0.02 ± 0.02 | 0.01 ± 0.01 |
| pO2art-ven (mmHg) | 347 ± 9.2 | 379 ± 8.2 | 316 ± 13.2 | 369 ± 9.3* | 311 ± 10.9 | 367 ± 8.5* | 364 ± 8.6 | 415 ± 8.5* | 362 ± 11.4 | 433 ± 8.1* | 368 ± 11 | 441 ± 9.1* |
| pCO2 (mmHg) | 41 ± 0.5 | 39 ± 0.5 | 41 ± 0.8 | 40 ± 1.0 | 40 ± 0.7 | 38 ± 0.7 | 39 ± 1.0 | 38 ± 0.7 | 40 ± 0.9 | 39 ± 0.6 | 40 ± 0.8 | 39 ± 0.7 |
| ATP content μg/g | 56 ± 4.6 | 78 ± 7.7* | ||||||||||
ARI, activation recovery interval; TAT, total activation time; cQT, corrected QT interval; PQ, PQ interval; QRS, QRS complex; BCL, basic cycle length; HR, heart rate; CF, coronary flow; pO2art-ven difference of arterio-venous partial oxygen pressure, pCO2 partial carbon dioxide pressure, ole olesoxime.
CP− cardioplegia, CP+ cardioplegia+olesoxime.
*
Significant differences CP− vs. CP+ (p < 0.05).