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Knockdown of DDX41 inhibits DEVDase activity in a p21-dependent manner. A–C, fluorometric determination of caspase-3-like DEVDase activities in HCT116 cells that were transfected with the indicated siRNAs before they were exposed to γIR. Cells were analyzed 2 days after γIR. The arbitrary units (AU) shown are the mean of three (B) and four (A and C) independent experiments ± S.D. Note the different y axis scales. *, p < 0.05; **, p < 0.01.
