Table 3.

Overview of the tested siRNAs on PrP^C endocytosis rate and cell-surface level

For the study of PrP^C endocytosis and cell-surface expression, seven siRNAs acting in protein recycling pathways and their downstream organelles were selected.

Abbreviation	Description
AP2M1	Encodes the adaptor protein 2 (AP-2), which is involved in clathrin-dependent endocytosis
EHD1	Encodes the EH domain-containing protein 1, plays a role in endocytosis
GIT2	Encodes the ARF GTPase-activating protein GIT2
M6PR	Encodes the mannose 6-phosphate receptor, interacts with AP1 clathrin adaptor complex
RAB5A	G-protein, required for the fusion of plasma membrane an early endosomes
VPS28	Encodes the vacuolar protein sorting-associated protein 28 homolog, involved in endosomal sorting of cell-surface receptors
VPS35	Encodes the vacuolar protein sorting-associated protein 35 homolog, involved in retrograde transport of proteins from endosomes to the trans-Golgi network