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Location and residues around Pro-2204 in filamin A structure. A, crystal structure of autoinhibited Ig19–21 from filamin A (PDB 2J3S). The segment of Ig20 occluding Ig21 ligand binding site is shown in blue. The Pro-2204 side chain is buried in the Ig20 segment and is proximal to the Ser-2152 phosphosite. B, substitution of Pro-2204 into leucine causes some steric clash with surrounding residues (labeled) and likely destabilizes Ig20.
